An illustration for the Cell Reports Medicine journal cover.
The idea was to give an impression of one of the key findings in the
work published by Zhang et al. in 2022.
The image shows an MHC-proficient tumor cell (bottom) recognized and eliminated by an antigen-specific T cell (petrol), which secretes TNF (blue swirl). When RNF31 in cancer cells is targeted by a small-molecule inhibitor, MHC-deficient cancer cells that are not recognized by T cells become susceptible to TNF-mediated bystander killing.
The journal can be found here:
